Some health systems are integrating OpenEvidence into electronic health records (EHRs), clinical workflows and medical education. Since its launch in 2023 in collaboration with the Mayo Clinic Platform, the AI-powered medical search engine and decision support solution has become popular with clinicians.
A recent JAMA study found that approximately 952,000 U.S. clinicians, including 556,200 physicians, submitted 271 million queries to OpenEvidence between January 2024 and June 2026. Most queries concerned clinical decision-making, particularly treatment and management.
The company reported that OpenEvidence had 1.12 million verified U.S. users — including physicians, nurses, physician assistants and nurse practitioners — as of September 2026.
Six recent collaborations between OpenEvidence and health systems show how providers aim to use the platform to make clinical evidence easier to access, support treatment decisions and extend specialized knowledge.
Note: This is not an exhaustive list of AHA members working with OpenEvidence.
Transforming Medical Education
Baltimore-based Johns Hopkins Medicine has formed a strategic collaboration with OpenEvidence with two pillars: transforming medical education and ensuring every patient receives treatment informed by the most recent evidence-based guidelines. Johns Hopkins and the AI company plan to create a new medical education model and AI platforms that prepare physicians for leadership and continuous learning. Additionally, they intend to build “human-first AI systems” to improve care delivery by enabling clinicians to quickly consider and make decisions based on best practices and individual medical histories.
Embedding Clinical Evidence in the EHR
Chicago-based Northwestern Medicine has streamlined clinicians’ access to OpenEvidence. Northwestern Medicine clinicians can now launch the platform directly from the EHR to access information such as the latest medical guidelines, drug interactions and dosing.
Making More Time for Meaningful Conversations
Altamonte, Florida-based AdventHealth has embedded OpenEvidence into existing EHR workflows. This streamlines research on medical scenarios, freeing clinicians to spend more time on direct patient care.
Supporting Better Cancer Care
Memorial Sloan Kettering Cancer Center (MSK) in New York City plans to improve cancer care with OpenEvidence. The hospital is integrating the AI platform into its EHR and making OncoKB™, MSK’s precision oncology knowledge base, part of OpenEvidence.
Adding AI to Clinical Workflows
The University of Texas Medical Branch (UTMB) in Galveston has integrated OpenEvidence directly into its EHR. Physicians and other clinical users can now ask questions in natural language and receive answers with citations to authoritative sources.
Increasing Access to Medical Knowledge Worldwide
Philadelphia-based Penn Medicine has extended AI-powered clinical decision support to its team. Additionally, Penn Medicine teams plan to leverage the partnership with the AI provider to build a customized tool and extend clinical decision support to low- and middle-income regions through the Botswana-UPenn Partnership.
The Bottom Line on OpenEvidence for Hospitals and Health Systems
These collaborations point to a broader shift in how hospitals and health systems are approaching AI-powered clinical decision support. By embedding tools such as OpenEvidence directly into EHRs and clinical workflows, providers aim to give clinicians faster access to current guidelines, peer-reviewed evidence and specialized knowledge at the point of care. Some organizations are also exploring how the technology can support medical education, precision medicine and broader access to clinical expertise. For health systems, the emerging opportunity is not simply access to AI, but integrating trusted, evidence-based information where clinicians learn and make decisions.
Source: www.aha.org
